Issue 4, 2014
From the journal:

Chemical Communications

β-Sultams exhibit discrete binding preferences for diverse bacterial enzymes with nucleophilic residues†

Roman Kolb,a   Nina C. Bacha  and  Stephan A. Sieber*a  

* Corresponding authors

a Department of Chemistry, Center for Integrated Protein Science Munich (CIPSM), Technische Universität Müchen, Garching, Germany
E-mail: stephan.sieber@tum.de

Abstract

β-Sultams are potent electrophiles that modify nucleophilic residues in selected enzyme active sites. We here identify and characterize some of the specific bacterial targets and show a unique inhibition of the azoreductase family.

Graphical abstract: β-Sultams exhibit discrete binding preferences for diverse bacterial enzymes with nucleophilic residues

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Article information

DOI
https://doi.org/10.1039/C3CC46002A
Article type
Communication
Submitted
06 Aug 2013
Accepted
25 Oct 2013
First published
30 Oct 2013

Chem. Commun., 2014,50, 427-429

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β-Sultams exhibit discrete binding preferences for diverse bacterial enzymes with nucleophilic residues

R. Kolb, N. C. Bach and S. A. Sieber, Chem. Commun., 2014, 50, 427 DOI: 10.1039/C3CC46002A

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