Issue 12, 2014
From the journal:

Chemical Communications

Creation of artificial cellulosomes on DNA scaffolds by zinc finger protein-guided assembly for efficient cellulose hydrolysis†

Qing Sun,a   Bhawna Madan,b   Shen-Long Tsai,c   Matthew P. DeLisad  and  Wilfred Chen*a  

* Corresponding authors

a Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware 19716, USA
E-mail: wilfred@udel.edu
Tel: +1-302-831-7650

b Amity Institute of Biotechnology, Uttar Pradesh, India
E-mail: bhawna.madan@gmail.com

c Chemical Engineering, National Taiwan University of Science and Technology, Taiwan
E-mail: stsai@mail.ntust.edu.tw

d School of Chemical and Biomolecular Engineering, Cornell University, 254 Olin Hall, Ithaca, New York 14853, USA
E-mail: md255@cornell.edu

Abstract

For the first time, artificial cellulosome structures were created on DNA scaffolds based on zinc finger protein (ZFP)-guided assembly. These resulting two-component cellulosome structures exhibited enhancement in cellulose hydrolysis compared to the non-complexed mixture depending on the number of CBMs and cellulases assembled.

Graphical abstract: Creation of artificial cellulosomes on DNA scaffolds by zinc finger protein-guided assembly for efficient cellulose hydrolysis

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Article information

DOI
https://doi.org/10.1039/C3CC47215A
Article type
Communication
Submitted
20 Sep 2013
Accepted
27 Nov 2013
First published
29 Nov 2013

Chem. Commun., 2014,50, 1423-1425

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Creation of artificial cellulosomes on DNA scaffolds by zinc finger protein-guided assembly for efficient cellulose hydrolysis

Q. Sun, B. Madan, S. Tsai, M. P. DeLisa and W. Chen, Chem. Commun., 2014, 50, 1423 DOI: 10.1039/C3CC47215A

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