Issue 1, 2014
From the journal:

Chemical Communications

Examination of native chemical ligation using peptidyl prolyl thioesters†‡

Takahiro Nakamura,a   Akira Shigenaga,a   Kohei Sato,a   Yusuke Tsuda,a   Ken Sakamotoa  and  Akira Otaka*a  

* Corresponding authors

a Institute of Health Biosciences and Graduate School of Pharmaceutical Sciences, The University of Tokushima, 1-78-1 Shomachi, Tokushima 770-8505, Japan
E-mail: aotaka@tokushima-u.ac.jp
Fax: +81-88-633-9505
Tel: +81-88-633-7283

Abstract

Peptidyl prolyl thioesters, which have been regarded as too unreactive for practical use in native chemical ligations (NCLs), were proven to be versatile reagents in peptide coupling. Tuning the reactivity of prolyl thioesters enabled a one-pot/sequential NCL reaction based on kinetically controlled ligation.

Graphical abstract: Examination of native chemical ligation using peptidyl prolyl thioesters

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Article information

DOI
https://doi.org/10.1039/C3CC47228K
Article type
Communication
Submitted
22 Sep 2013
Accepted
18 Oct 2013
First published
22 Oct 2013

Chem. Commun., 2014,50, 58-60

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Examination of native chemical ligation using peptidyl prolyl thioesters

T. Nakamura, A. Shigenaga, K. Sato, Y. Tsuda, K. Sakamoto and A. Otaka, Chem. Commun., 2014, 50, 58 DOI: 10.1039/C3CC47228K

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