Issue 3, 2014
From the journal:

Chemical Communications

Probing kojic acid binding to tyrosinase enzyme: insights from a model complex and QM/MM calculations†

Constance Bochot,a   Aurélie Gouron,a   Luigi Bubacco,b   Anne Milet,a   Christian Philouze,a   Marius Réglier,c   Guy Serratrice,a   Hélène Jamet*a  and  Catherine Belle*a  

* Corresponding authors

a Département de Chimie Moléculaire, équipes CIRE et CT, Université Joseph Fourier UMR-CNRS 5250, ICMG FR-2607, BP 53, Grenoble Cedex 9, France
E-mail: catherine.belle@ujf-grenoble.fr

b Department of Biology, University of Padova, 35121 Padova, Italy

c Aix-Marseille Université, Centrale Marseille, CNRS, ISM2 UMR 7313, Marseille, France

Abstract

An unambiguous picture of the interaction between the inhibitor kojic acid and a model of the dicopper active site of tyrosinase is reported. The observed binding mode probed on bacterial enzyme is confirmed and further refined by QM/MM calculations.

Graphical abstract: Probing kojic acid binding to tyrosinase enzyme: insights from a model complex and QM/MM calculations

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Article information

DOI
https://doi.org/10.1039/C3CC47469K
Article type
Communication
Submitted
30 Sep 2013
Accepted
29 Oct 2013
First published
30 Oct 2013

Chem. Commun., 2014,50, 308-310

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Probing kojic acid binding to tyrosinase enzyme: insights from a model complex and QM/MM calculations

C. Bochot, A. Gouron, L. Bubacco, A. Milet, C. Philouze, M. Réglier, G. Serratrice, H. Jamet and C. Belle, Chem. Commun., 2014, 50, 308 DOI: 10.1039/C3CC47469K

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