Issue 11, 2014
From the journal:

Chemical Communications

Detection of the ovarian cancer biomarker CA-125 using chemiluminescence resonance energy transfer to graphene quantum dots†

Israa Al-Ogaidi,‡ab   Honglei Gou,‡b   Zoraida P. Aguilar,c   Shouwu Guo,d   Alice K. Melconian,a   Abdul Kareem A. Al-kazaz,a   Fanke Mengb  and  Nianqiang Wu*b  

* Corresponding authors

a Department of Biotechnology, College of Science, University of Baghdad, Baghdad, Iraq

b Department of Mechanical and Aerospace Engineering, West Virginia University, Morgantown, WV 26506-6106, USA
E-mail: nick.wu@mail.wvu.edu
Fax: +1-304-293-6689

c Zystein, LLC., PO Box 10071, Fayetteville, Arkansas 72703, USA

d Key Laboratory for Thin Film and Microfabrication of the Ministry of Education, Research Institute of Micro/Nano Science and Technology, Shanghai Jiao Tong University, Shanghai 200240, China

Abstract

An immunoassay has been developed for the detection of the ovarian cancer biomarker CA-125 by utilizing the chemiluminescence resonance energy transfer to graphene quantum dots. This biosensor shows a wide linear range from 0.1 U mL−1 to 600 U mL−1 with a limit of detection of 0.05 U mL−1 for CA-125 in a buffer solution.

Graphical abstract: Detection of the ovarian cancer biomarker CA-125 using chemiluminescence resonance energy transfer to graphene quantum dots

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Article information

DOI
https://doi.org/10.1039/C3CC47701K
Article type
Communication
Submitted
07 Oct 2013
Accepted
27 Nov 2013
First published
28 Nov 2013

Chem. Commun., 2014,50, 1344-1346

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Detection of the ovarian cancer biomarker CA-125 using chemiluminescence resonance energy transfer to graphene quantum dots

I. Al-Ogaidi, H. Gou, Z. P. Aguilar, S. Guo, A. K. Melconian, A. K. A. Al-kazaz, F. Meng and N. Wu, Chem. Commun., 2014, 50, 1344 DOI: 10.1039/C3CC47701K

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