Issue 8, 2014
From the journal:

Chemical Communications

The promotion of antimicrobial activity on silicon substrates using a “click” immobilized short peptide†

Lin Wang,ab   Junjian Chen,ab   Lin Shi,ab   Zhifeng Shi,ab   Li Ren*b  and  Yingjun Wang*a  

* Corresponding authors

a National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, China
E-mail: imwangyj@163.com

b School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China
E-mail: psliren@scut.edu.cn

Abstract

We demonstrated, for the first time, that the short antimicrobial peptide Tet213 could be conjugated onto the silicon surface by Cu(I)-catalyzed azide–alkyne cycloaddition (CuAAC). The modified surface exhibited excellent antimicrobial activity against S. aureus and E. coli, and low cytotoxicity to rat bone mesenchymal stem cells (rBMSCs).

Graphical abstract: The promotion of antimicrobial activity on silicon substrates using a “click” immobilized short peptide

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Article information

DOI
https://doi.org/10.1039/C3CC47922F
Article type
Communication
Submitted
15 Oct 2013
Accepted
06 Nov 2013
First published
07 Nov 2013

Chem. Commun., 2014,50, 975-977

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The promotion of antimicrobial activity on silicon substrates using a “click” immobilized short peptide

L. Wang, J. Chen, L. Shi, Z. Shi, L. Ren and Y. Wang, Chem. Commun., 2014, 50, 975 DOI: 10.1039/C3CC47922F

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