Issue 6, 2014
From the journal:

Chemical Communications

Ordered self-assembly of proteins for computation in mammalian cells†

Kui Zhu,‡a   Jianzhong Shen,‡b   Richard Dietrich,a   Andrea Didier,a   Xingyu Jiang*c  and  Erwin Märtlbauer*a  

* Corresponding authors

a Department of Veterinary Sciences, Ludwig-Maximilians-University Munich, Schönleutnerstr. 8, 85764 Oberschleissheim, Germany
E-mail: e.maertlbauer@mh.vetmed.uni-muenchen.de, xingyujiang@nanoctr.cn
Fax: +49 89 2180 78576
Tel: +49 89 2180 78602

b Department of Pharmacology and Toxicology, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China

c CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, Beijing 100190, China

Abstract

A cellular logic system capable of combinatorial and sequential logic operations based on bacterial protein-triggered cytotoxicity was constructed. Advanced devices such as a keypad lock, half-adder and several basic Boolean properties were demonstrated on the cells.

Graphical abstract: Ordered self-assembly of proteins for computation in mammalian cells

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Article information

DOI
https://doi.org/10.1039/C3CC48100J
Article type
Communication
Submitted
22 Oct 2013
Accepted
04 Nov 2013
First published
05 Nov 2013

Chem. Commun., 2014,50, 676-678

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Ordered self-assembly of proteins for computation in mammalian cells

K. Zhu, J. Shen, R. Dietrich, A. Didier, X. Jiang and E. Märtlbauer, Chem. Commun., 2014, 50, 676 DOI: 10.1039/C3CC48100J

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