A telomere-triggered isothermal exponential amplification-based DNAzyme biosensor is developed for highly sensitive detection of telomerase in cancer cells even at the single-cell level. This biosensor can be further applied for the screening of telomerase inhibitors for anticancer drug development.
Y. Zhang, L. Wang and C. Zhang, Chem. Commun., 2014, 50, 1909 DOI: 10.1039/C3CC48518H
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