We report two platinum(IV) complexes conjugated with a vitamin E analog, α-tocopherol succinate (α-TOS). One of the conjugates displays the activity of both cisplatin and α-TOS in cancer cells, causing damage to DNA and mitochondria simultaneously. Accordingly, it serves as a promising dual-targeting anticancer agent.
K. Suntharalingam, Y. Song and S. J. Lippard, Chem. Commun., 2014, 50, 2465 DOI: 10.1039/C3CC48740G
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