Issue 15, 2014
From the journal:

Chemical Communications

Modular automated solid phase synthesis of dermatan sulfate oligosaccharides†

Jeyakumar Kandasamy,a   Frank Schuhmacher,ab   Heung Sik Hahm,ab   James C. Kleina  and  Peter H. Seeberger*ab  

* Corresponding authors

a Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam-Golm, Germany
E-mail: peter.seeberger@mpikg.mpg.de
Fax: +49 30 838-59302
Tel: +49 30 838-59301

b Freie Universität Berlin, Institute of Chemistry and Biochemistry, Arnimallee 22, 14195 Berlin, Germany

Abstract

Dermatan sulfates are glycosaminoglycan polysaccharides that serve a multitude of biological roles as part of the extracellular matrix. Orthogonally protected D-galactosamine and L-iduronic acid building blocks and a photo-cleavable linker are instrumental for the automated synthesis of dermatan sulfate oligosaccharides. Conjugation-ready oligosaccharides were obtained in good yield.

Graphical abstract: Modular automated solid phase synthesis of dermatan sulfate oligosaccharides

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Article information

DOI
https://doi.org/10.1039/C3CC48860H
Article type
Communication
Submitted
20 Nov 2013
Accepted
24 Dec 2013
First published
03 Jan 2014

Chem. Commun., 2014,50, 1875-1877

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Modular automated solid phase synthesis of dermatan sulfate oligosaccharides

J. Kandasamy, F. Schuhmacher, H. S. Hahm, J. C. Klein and P. H. Seeberger, Chem. Commun., 2014, 50, 1875 DOI: 10.1039/C3CC48860H

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