Cisplatin can be modified with various ligands to alter the size and charge distribution of the complex. Several amino acid-linked platinum(II) complexes were synthesized, and a reactivity study with 16S ribosomal RNA was carried out. The amino acid-linked analogues show altered specificity compared to the parental compound cisplatin.
K. Rijal, X. Bao and C. S. Chow, Chem. Commun., 2014, 50, 3918 DOI: 10.1039/C3CC49035A
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