Issue 17, 2014
From the journal:

Chemical Communications

Efficient synthesis of chiral cyclic acetals by metal and Brønsted acid co-catalyzed enantioselective four-component cascade reactions†

Lin Qiu,a   Xin Guo,a   Chaoqun Ma,a   Huang Qiu,a   Shunying Liu,*a   Liping Yanga  and  Wenhao Hu*a  

* Corresponding authors

a Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, 3663 North Zhongshan Rd., Shanghai, China
E-mail: syliu@sist.ecnu.edu.cn, whu@chem.ecnu.edu.cn
Fax: +86-21-62221237
Tel: +86-21-62221235

Abstract

Four-component Mannich reactions subsequently followed by an intramolecular oxo-Michael addition were developed to efficiently produce chiral cyclic acetals with high diastereoselectivity and enantioselectivity.

Graphical abstract: Efficient synthesis of chiral cyclic acetals by metal and Brønsted acid co-catalyzed enantioselective four-component cascade reactions

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Article information

DOI
https://doi.org/10.1039/C3CC49063G
Article type
Communication
Submitted
27 Nov 2013
Accepted
20 Dec 2013
First published
23 Dec 2013

Chem. Commun., 2014,50, 2196-2198

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Efficient synthesis of chiral cyclic acetals by metal and Brønsted acid co-catalyzed enantioselective four-component cascade reactions

L. Qiu, X. Guo, C. Ma, H. Qiu, S. Liu, L. Yang and W. Hu, Chem. Commun., 2014, 50, 2196 DOI: 10.1039/C3CC49063G

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