Issue 24, 2014

Cu-catalyzed amidation of halogenated imidazoles

Abstract

An efficient methodology involving the Cu-catalyzed amidation of halogenated imidazoles has been successfully developed. The amidated product of 5-bromo-1-alkylimidazole was further applied to the synthesis of a new chiral imidazole nucleophilic catalyst for the kinetic resolution of secondary alcohols.

Graphical abstract: Cu-catalyzed amidation of halogenated imidazoles

Supplementary files

Article information

Article type
Communication
Submitted
29 Nov 2013
Accepted
17 Jan 2014
First published
22 Jan 2014

Chem. Commun., 2014,50, 3163-3165

Cu-catalyzed amidation of halogenated imidazoles

M. Wang, Z. Zhang, F. Xie and W. Zhang, Chem. Commun., 2014, 50, 3163 DOI: 10.1039/C3CC49107B

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