A cyclization reaction between enamides and alkynes catalyzed by palladium(II) acetate is described. In this method, the molecular oxygen serves as an efficient oxidant for the Pd(II)/Pd(0) catalytic cycle. The simple reaction conditions permit this methodology to be used as a general tool for the preparation of multi-substituted pyrroles.
Y. Xu, T. He, Q. Zhang and T. Loh, Chem. Commun., 2014, 50, 2784 DOI: 10.1039/C3CC49683J
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