Issue 23, 2014
From the journal:

Chemical Communications

Rational design of biotin–disulfide–coumarin conjugates: a cancer targeted thiol probe and bioimaging†

Danbi Jung,‡a   Sukhendu Maiti,‡a   Jae Hong Lee,a   Joung Hae Leeb  and  Jong Seung Kim*a  

* Corresponding authors

a Department of Chemistry, Korea University, Seoul 136-701, Korea
E-mail: jongskim@korea.ac.kr
Fax: +82-2-3290-3121

b Korea Research Institute of Standards and Science, Daejon 305-600, Korea

Abstract

Biotin–disulfide–coumarin conjugates are designed and synthesized as novel fluorescent sensors for cancer targeted intracellular thiol imaging in living organisms. In vitro experiments disclose that probe 6 is preferentially taken up by biotin receptor-positive A549 tumor cells through receptor mediated endocytosis.

Graphical abstract: Rational design of biotin–disulfide–coumarin conjugates: a cancer targeted thiol probe and bioimaging

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Article information

DOI
https://doi.org/10.1039/C3CC49790A
Article type
Communication
Submitted
27 Dec 2013
Accepted
27 Jan 2014
First published
29 Jan 2014

Chem. Commun., 2014,50, 3044-3047

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Rational design of biotin–disulfide–coumarin conjugates: a cancer targeted thiol probe and bioimaging

D. Jung, S. Maiti, J. H. Lee, J. H. Lee and J. S. Kim, Chem. Commun., 2014, 50, 3044 DOI: 10.1039/C3CC49790A

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