Catalytic enantioselective trifluoromethylthiolation of oxindoles using shelf-stable N-(trifluoromethylthio)phthalimide and a cinchona alkaloid catalyst

Abstract

The organocatalytic enantioselective trifluoromethylthiolation of oxindoles employing N-(trifluoromethylthio)phthalimide as a stable, easy to handle CF₃S-source has been developed. Optically active products with a quaternary stereogenic center bearing a CF₃S-group are obtained in good yields and with good to excellent enantioselectivities.