Issue 29, 2014
From the journal:

Chemical Communications

Dual responsive supramolecular nanogels for intracellular drug delivery†

Xiaofei Chen,a   Li Chen,*a   Xuemei Yao,a   Zhe Zhang,a   Chaoliang He,*b   Jingping Zhanga  and  Xuesi Chenb  

* Corresponding authors

a Department of Chemistry, Northeast Normal University, Changchun 130024, P. R. China
E-mail: chenl686@nenu.edu.cn
Fax: +86 431 85099667
Tel: +86 431 85099667

b Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China
E-mail: clhe@ciac.jl.cn

Abstract

Supramolecular nanogels cross-linked by host–guest interaction between dextran grafted benzimidazole (Dex-g-BM) and thiol-β-cyclodextrin were designed. Their special supramolecular pH-sensitivity under acidic conditions (pH < 6, within the range of malignant cellular endosomes) and reduction sensitivity in response to biologically relevant stimuli will be of great advantage to the future of cancer chemotherapeutics.

Graphical abstract: Dual responsive supramolecular nanogels for intracellular drug delivery

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Article information

DOI
https://doi.org/10.1039/C4CC00016A
Article type
Communication
Submitted
02 Jan 2014
Accepted
29 Jan 2014
First published
31 Jan 2014

Chem. Commun., 2014,50, 3789-3791

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Dual responsive supramolecular nanogels for intracellular drug delivery

X. Chen, L. Chen, X. Yao, Z. Zhang, C. He, J. Zhang and X. Chen, Chem. Commun., 2014, 50, 3789 DOI: 10.1039/C4CC00016A

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