Issue 34, 2014
From the journal:

Chemical Communications

Red Si–rhodamine drug conjugates enable imaging in GFP cells†

Eunha Kim,a   Katherine S. Yang,a   Randy J. Giedta  and  Ralph Weissleder*ab  

* Corresponding authors

a Center for Systems Biology, Massachusettes General Hospital/Harvard Medical School, 185 Cambridge St, Boston, MA 02114, USA
E-mail: rweissleder@mgh.harvard.edu

b Department of Systems Biology, Harvard Medical School, 200 Longwood Ave., Alpert 536, Boston, MA 02115, USA

Abstract

Here we evaluated a series of Si-derivatized rhodamine (SiR) dyes for their ability to visualize a model drug in live cells. We show that a charge neutral SiR derivative (but not others) can indeed be used to follow the intracellular location of the model therapeutic drug in GFP cells.

Graphical abstract: Red Si–rhodamine drug conjugates enable imaging in GFP cells

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Article information

DOI
https://doi.org/10.1039/C4CC00144C
Article type
Communication
Submitted
07 Jan 2014
Accepted
13 Mar 2014
First published
19 Mar 2014

Chem. Commun., 2014,50, 4504-4507

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Red Si–rhodamine drug conjugates enable imaging in GFP cells

E. Kim, K. S. Yang, R. J. Giedt and R. Weissleder, Chem. Commun., 2014, 50, 4504 DOI: 10.1039/C4CC00144C

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