Issue 32, 2014
From the journal:

Chemical Communications

A highly sensitive electrochemical genosensor based on Co-porphyrin-labelled DNA†

Iwona Grabowska,a   Daniel G. Singleton,b   Anna Stachyra,c   Anna Góra-Sochacka,c   Agnieszka Sirko,c   Włodzimierz Zagórski-Ostoja,c   Hanna Radecka,*a   Eugen Stulz*b  and  Jerzy Radecki*a  

* Corresponding authors

a Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Tuwima 10, 10-747 Olsztyn, Poland
E-mail: j.radecki@pan.olsztyn.pl
Fax: +48-895240124
Tel: +48-895234612

b School of Chemistry and Institute for Life Sciences, University of Southampton, Highfield, Southampton SO17 1BJ, UK
E-mail: est@soton.ac.uk
Tel: +44-2380599369

c Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawińskiego 5A, 02-106 Warsaw, Poland

Abstract

We report the use of Co-porphyrins as electrochemical tags for a highly sensitive and selective genosensor. An avian influenza virus-based DNA sequence characteristic of H5N1 was detected at femtomolar levels from competing non-complementary sequences through hybridisation with the labeled DNA.

Graphical abstract: A highly sensitive electrochemical genosensor based on Co-porphyrin-labelled DNA

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DOI
https://doi.org/10.1039/C4CC00172A
Article type
Communication
Submitted
08 Jan 2014
Accepted
28 Feb 2014
First published
03 Mar 2014
This article is Open Access
Creative Commons BY license

Chem. Commun., 2014,50, 4196-4199

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A highly sensitive electrochemical genosensor based on Co-porphyrin-labelled DNA

I. Grabowska, D. G. Singleton, A. Stachyra, A. Góra-Sochacka, A. Sirko, W. Zagórski-Ostoja, H. Radecka, E. Stulz and J. Radecki, Chem. Commun., 2014, 50, 4196 DOI: 10.1039/C4CC00172A

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