Issue 22, 2014
From the journal:

Chemical Communications

A tuned affinity-based staurosporine probe for in situ profiling of protein kinases†

Xiamin Cheng,a   Lin Li,a   Mahesh Uttamchandania  and  Shao Q. Yao*a  

* Corresponding authors

a Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore
E-mail: chmyaosq@nus.edu.sg
Fax: +1 65 67791691
Tel: +1 65 65162925

Abstract

A clickable and cell-permeable affinity-based probe (AfBP) was designed from staurosporine, by incorporating an electrophilic chloroacetamide warhead to facilitate in situ proteome labeling of a range of potential kinase targets.

Graphical abstract: A tuned affinity-based staurosporine probe for in situ profiling of protein kinases

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Article information

DOI
https://doi.org/10.1039/C4CC00184B
Article type
Communication
Submitted
09 Jan 2014
Accepted
28 Jan 2014
First published
28 Jan 2014

Chem. Commun., 2014,50, 2851-2853

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A tuned affinity-based staurosporine probe for in situ profiling of protein kinases

X. Cheng, L. Li, M. Uttamchandani and S. Q. Yao, Chem. Commun., 2014, 50, 2851 DOI: 10.1039/C4CC00184B

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