We report the first protein selective Spiegelmers of diagnostic relevance by rational identification of a target epitope and reverse screening of Spiegelmer candidates following the selection procedure. Application of the presented approach resulted in isolation of cardiac troponin I selective Spiegelmers with low nanomolar dissociation constant and functionality in serum.
Z. Szeitner, G. Lautner, S. K. Nagy, R. E. Gyurcsányi and T. Mészáros, Chem. Commun., 2014, 50, 6801 DOI: 10.1039/C4CC00447G
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