Issue 53, 2014
From the journal:

Chemical Communications

Efficient access to the non-reducing end of low molecular weight heparin for fluorescent labeling†

Zongqiang Wang,a   Chen Shi,a   Xuri Wua  and  Yijun Chen*a  

* Corresponding authors

a State Key Laboratory of Natural Medicines and Laboratory of Chemical Biology, China Pharmaceutical University, 24 Tongjia Street, Nanjing, Jiangsu Province, People's Republic of China
E-mail: yjchen@cpu.edu.cn
Fax: +86 25 83271031
Tel: +86 25 83271031

Abstract

A novel thiol fluorophore was synthesized to be selectively attached to the non-reducing end of low molecular weight heparin (LMWH) via a Michael addition. Double labeling of LMWH was demonstrated to be a feasible approach for the determination of heparinase II activity by FRET.

Graphical abstract: Efficient access to the non-reducing end of low molecular weight heparin for fluorescent labeling

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C4CC00708E
Article type
Communication
Submitted
28 Jan 2014
Accepted
02 Apr 2014
First published
04 Apr 2014

Chem. Commun., 2014,50, 7004-7006

Permissions

Request permissions

Efficient access to the non-reducing end of low molecular weight heparin for fluorescent labeling

Z. Wang, C. Shi, X. Wu and Y. Chen, Chem. Commun., 2014, 50, 7004 DOI: 10.1039/C4CC00708E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements