Issue 30, 2014
From the journal:

Chemical Communications

Polymorphism control of an active pharmaceutical ingredient beneath calixarene-based Langmuir monolayers†

Ludovico G. Tulli,a   Negar Moridi,a   Wenjie Wang,b   Kaisa Helttunen,c   Markus Neuburger,d   David Vaknin,b   Wolfgang Meierd  and  Patrick Shahgaldian*a  

* Corresponding authors

a Institute of Chemistry and Bioanalytics, School of Life Science, University of Applied Sciences and Arts Northwestern Switzerland, Muttenz, Switzerland
E-mail: patrick.shahgaldian@fhnw.ch

b Ames Laboratory, and Department of Physics and Astronomy, Iowa State University, USA

c Department of Chemistry, Nanoscience Center University of Jyväskylä, Finland

d Department of Chemistry, University of Basel, Switzerland

Abstract

This communication demonstrates the possibility to nucleate and grow different crystalline polymorphic forms of gabapentin (GBP) using, as nucleation templates, Langmuir monolayers of an amphiphilic calixarene at different packing densities.

Graphical abstract: Polymorphism control of an active pharmaceutical ingredient beneath calixarene-based Langmuir monolayers

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Article information

DOI
https://doi.org/10.1039/C4CC00928B
Article type
Communication
Submitted
04 Feb 2014
Accepted
20 Feb 2014
First published
05 Mar 2014

Chem. Commun., 2014,50, 3938-3940

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Polymorphism control of an active pharmaceutical ingredient beneath calixarene-based Langmuir monolayers

L. G. Tulli, N. Moridi, W. Wang, K. Helttunen, M. Neuburger, D. Vaknin, W. Meier and P. Shahgaldian, Chem. Commun., 2014, 50, 3938 DOI: 10.1039/C4CC00928B

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