Cationic oligomers with a rigid aromatic backbone were first applied as non-viral gene delivery vectors. These materials showed better DNA condensation ability than their flexible analogues. In vitro transfection experiments revealed that the materials with more rigid backbone exhibited considerably higher TE and lower cytotoxicity than 25 kDa PEI.
W. Yi, X. Yu, B. Wang, J. Zhang, Q. Yu, X. Zhou and X. Yu, Chem. Commun., 2014, 50, 6454 DOI: 10.1039/C4CC01210K
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