Issue 41, 2014
From the journal:

Chemical Communications

Asymmetric synthesis of heteroaryl atropisomers via a gold-catalyzed cycloisomerization–amination cascade reaction†

Rui Guo,a   Kang-Nan Li,a   Bin Liu,a   Hua-Jie Zhu,*b   Yu-Meng Fana  and  Liu-Zhu Gong*a  

* Corresponding authors

a Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China
E-mail: gonglz@ustc.edu.cn
Fax: +86 551-6360-6266
Tel: +86 551-6360-0671

b Chinese Centre for Chirality, Key Laboratory of Medicinal Chemistry and Molecular Diagnostics of Education Administration of China, College of Pharmacy Sciences, Hebei University, Baoding, Hebei 071002, China
E-mail: hjzhu@mail.kib.ac.cn
Fax: +86 312-5994812

Abstract

The chiral gold(I) complex enables enantioselective cycloisomerization–amination of 2-(alkynyl)phenyl boronic acids and diazenes in high yields. A wide scope of substrates bearing various functional groups was tolerated to generate structurally different hydrazide derivatives as a new type of atropisomer.

Graphical abstract: Asymmetric synthesis of heteroaryl atropisomers via a gold-catalyzed cycloisomerization–amination cascade reaction

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Article information

DOI
https://doi.org/10.1039/C4CC01397B
Article type
Communication
Submitted
23 Feb 2014
Accepted
19 Mar 2014
First published
20 Mar 2014

Chem. Commun., 2014,50, 5451-5454

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Asymmetric synthesis of heteroaryl atropisomers via a gold-catalyzed cycloisomerization–amination cascade reaction

R. Guo, K. Li, B. Liu, H. Zhu, Y. Fan and L. Gong, Chem. Commun., 2014, 50, 5451 DOI: 10.1039/C4CC01397B

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