Efficient synthesis of fluorescent-PET probes based on [18F]BODIPY dye

Shuanglong Liu; Dan Li; Zhe Zhang; G. K. Surya Prakash; Peter S. Conti; Zibo Li

doi:10.1039/C4CC01411A

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Efficient synthesis of fluorescent-PET probes based on [¹⁸F]BODIPY dye†

Shuanglong Liu,^a Dan Li,^a Zhe Zhang,^b G. K. Surya Prakash,^b Peter S. Conti^a and Zibo Li*^a

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* Corresponding authors

^a Molecular Imaging Center, Radiology Department, University of Southern California, 2250 Alcazar St CSC103, Los Angeles, CA, USA
E-mail: ziboli@usc.edu
Fax: +1 323-442-3253
Tel: +1-323-442-3252

^b Loker Hydrocarbon Research Institute, Department of Chemistry, University of Southern California, Los Angeles, California 90089-1661, USA

Abstract

We report the direct conversion of fluorescent probes to PET/fluorescent probes after efficient [¹⁹F]/[¹⁸F] exchange at the BODIPY motif. The radiolabeling of a NIR BODIPY dye was also established, which was conjugated with the RGD peptide for PET/fluorescence imaging of integrin expression in vivo.

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Article information

DOI: https://doi.org/10.1039/C4CC01411A
Article type: Communication
Submitted: 24 Feb 2014
Accepted: 15 May 2014
First published: 16 May 2014

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Chem. Commun., 2014,50, 7371-7373

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Efficient synthesis of fluorescent-PET probes based on [¹⁸F]BODIPY dye

S. Liu, D. Li, Z. Zhang, G. K. Surya Prakash, P. S. Conti and Z. Li, Chem. Commun., 2014, 50, 7371 DOI: 10.1039/C4CC01411A

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Chemical Communications