Issue 42, 2014
From the journal:

Chemical Communications

Cyclometalated iridium(iii)–β-carboline complexes as potent autophagy-inducing agents†

Liang He,a   Si-Yan Liao,b   Cai-Ping Tan,*a   Yi-Ying Lu,a   Cui-Xia Xu,a   Liang-Nian Jia  and  Zong-Wan Mao*a  

* Corresponding authors

a MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, P. R. China
E-mail: cesmzw@mail.sysu.edu.cn, tancaip@mail.sysu.edu.cn
Fax: +86 20-8411-2245

b Department of Chemistry, Guangzhou Medical University, Guangzhou 510182, P. R. China

Abstract

Two cyclometalated Ir(III)–β-carboline complexes were identified as potent inducers of autophagic cell death. Autophagy induced by these complexes is ROS-mediated and caspase-independent.

Graphical abstract: Cyclometalated iridium(iii)–β-carboline complexes as potent autophagy-inducing agents

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Article information

DOI
https://doi.org/10.1039/C4CC01461H
Article type
Communication
Submitted
26 Feb 2014
Accepted
31 Mar 2014
First published
31 Mar 2014

Chem. Commun., 2014,50, 5611-5614

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Cyclometalated iridium(III)–β-carboline complexes as potent autophagy-inducing agents

L. He, S. Liao, C. Tan, Y. Lu, C. Xu, L. Ji and Z. Mao, Chem. Commun., 2014, 50, 5611 DOI: 10.1039/C4CC01461H

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