Issue 43, 2014
From the journal:

Chemical Communications

Room-temperature Cu(ii)-catalyzed aromatic C–H azidation for the synthesis of ortho-azido anilines with excellent regioselectivity†

Yunpeng Fan,a   Wen Wan,*a   Guobin Ma,‡b   Wei Gao,a   Haizhen Jiang,a   Shizheng Zhuc  and  Jian Hao*ac  

* Corresponding authors

a Department of Chemistry, Innovative Drug Research Center, Shanghai University, Shanghai, China
E-mail: jhao@shu.edu.cn, wanwen@staff.shu.edu.cn

b School of Material Science and Engineering, Shanghai University, China

c Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China

Abstract

Cu(II)-catalyzed aromatic C–H azidation with azido-benziodoxolone under mild conditions has been described. The primary amine exhibits an excellent ortho-directing effect, providing ortho-azidated anilines as the sole products.

Graphical abstract: Room-temperature Cu(ii)-catalyzed aromatic C–H azidation for the synthesis of ortho-azido anilines with excellent regioselectivity

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Article information

DOI
https://doi.org/10.1039/C4CC01481B
Article type
Communication
Submitted
26 Feb 2014
Accepted
12 Apr 2014
First published
14 Apr 2014

Chem. Commun., 2014,50, 5733-5736

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Room-temperature Cu(II)-catalyzed aromatic C–H azidation for the synthesis of ortho-azido anilines with excellent regioselectivity

Y. Fan, W. Wan, G. Ma, W. Gao, H. Jiang, S. Zhu and J. Hao, Chem. Commun., 2014, 50, 5733 DOI: 10.1039/C4CC01481B

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