Issue 38, 2014
From the journal:

Chemical Communications

Complexation of alkyl groups and ghrelin in a deep, water-soluble cavitand†

Kang-Da Zhang,b   Dariush Ajami,b   Jesse V. Gavetteb  and  Julius Rebek, Jr.*ab  

* Corresponding authors

a Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, 200433 China

b Skaggs Institute for Chemical Biology, The Scripps Research Institute, and Department of Chemistry, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
E-mail: jrebek@scripps.edu
Fax: +1 858-784-2876

Abstract

A cavitand with ionic, but nonionizable “feet” folds around hydrophobic guests in D2O. Short alkanes and ibuprofen are included and exchange rates are slow on the NMR timescale. Normal octanoyl groups show good affinity for the cavitand and the gastric peptide ghrelin is bound at low pH and physiological temperature.

Graphical abstract: Complexation of alkyl groups and ghrelin in a deep, water-soluble cavitand

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Article information

DOI
https://doi.org/10.1039/C4CC01643B
Article type
Communication
Submitted
04 Mar 2014
Accepted
25 Mar 2014
First published
26 Mar 2014

Chem. Commun., 2014,50, 4895-4897

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Complexation of alkyl groups and ghrelin in a deep, water-soluble cavitand

K. Zhang, D. Ajami, J. V. Gavette and J. Rebek, Chem. Commun., 2014, 50, 4895 DOI: 10.1039/C4CC01643B

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