Abstract
A 15-step synthesis of the iGluR antagonist kaitocephalin from aspartic acid is reported. The linchpin pyrrolidine ring of the target molecule is efficiently assembled with in a single operation via an asymmetric [C+NC+CC] reaction.
![Graphical abstract: A concise [C+NC+CC] coupling-enabled synthesis of kaitocephalin](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C4CC01692K&imageInfo.ImageIdentifier.Year=2014)
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Supplementary files
Article information
- Article type
- Communication
- Submitted
- 06 Mar 2014
- Accepted
- 27 Mar 2014
- First published
- 02 Apr 2014
Chem. Commun., 2014,50, 4908-4910
Author version available
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A concise [C+NC+CC] coupling-enabled synthesis of kaitocephalin
P. Garner, L. Weerasinghe, I. Van Houten and J. Hu, Chem. Commun., 2014, 50, 4908 DOI: 10.1039/C4CC01692K
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