Issue 42, 2014
From the journal:

Chemical Communications

Endoplasmic reticulum targeted chemotherapeutics: the remarkable photo-cytotoxicity of an oxovanadium(iv) vitamin-B6 complex in visible light†

Samya Banerjee,a   Akanksha Dixit,b   Radhika N. Shridharan,b   Anjali A. Karande*b  and  Akhil R. Chakravarty*a  

* Corresponding authors

a Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore 560012, India
E-mail: arc@ipc.iisc.ernet.in
Tel: +91-80-22932533

b Department of Biochemistry, Indian Institute of Science, Bangalore 560012, India
E-mail: anjali@biochem.iisc.ernet.in
Tel: +91-80-22932306

Abstract

An oxovanadium(IV) vitamin-B6 Schiff base complex, viz. [VO(HL)(acdppz)]Cl, having (acridinyl)dipyridophenazine (acdppz) shows specific localization to endoplasmic reticulum (ER) and remarkable apoptotic photocytotoxicity in visible light (400–700 nm) in HeLa and MCF-7 cancer cells (IC50 < 0.6 μM) while being non-toxic in the dark and to MCF-10A normal cells (IC50 > 40 μM).

Graphical abstract: Endoplasmic reticulum targeted chemotherapeutics: the remarkable photo-cytotoxicity of an oxovanadium(iv) vitamin-B6 complex in visible light

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Article information

DOI
https://doi.org/10.1039/C4CC02093F
Article type
Communication
Submitted
20 Mar 2014
Accepted
03 Apr 2014
First published
03 Apr 2014

Chem. Commun., 2014,50, 5590-5592

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Endoplasmic reticulum targeted chemotherapeutics: the remarkable photo-cytotoxicity of an oxovanadium(IV) vitamin-B6 complex in visible light

S. Banerjee, A. Dixit, R. N. Shridharan, A. A. Karande and A. R. Chakravarty, Chem. Commun., 2014, 50, 5590 DOI: 10.1039/C4CC02093F

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