Issue 51, 2014

Pd-catalyzed highly regio-, diastereo-, and enantioselective allylic alkylation of α-fluorophosphonates

Abstract

Highly efficient Pd-catalyzed asymmetric allylic alkylation reaction of ethyl-2-fluoro-2-(diethoxyphosphoryl)acetate with monosubstituted allylic substrates has been developed, affording corresponding α-fluorophosphonates with two chiral centers in high regio-, diastereo- and enantio-selectivities. The usefulness of the products in organic synthesis has been demonstrated.

Graphical abstract: Pd-catalyzed highly regio-, diastereo-, and enantioselective allylic alkylation of α-fluorophosphonates

Supplementary files

Article information

Article type
Communication
Submitted
24 Mar 2014
Accepted
04 May 2014
First published
06 May 2014

Chem. Commun., 2014,50, 6751-6753

Author version available

Pd-catalyzed highly regio-, diastereo-, and enantioselective allylic alkylation of α-fluorophosphonates

Y. Huang, Q. Zhang, P. Fang, T. Chen, J. Zhu and X. Hou, Chem. Commun., 2014, 50, 6751 DOI: 10.1039/C4CC02158D

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