Amphiphilic phthalocyanine–cyclodextrin conjugates for cancer photodynamic therapy

Leandro M. O. Lourenço; Patrícia M. R. Pereira; Elisabete Maciel; Mónica Válega; Fernando M. J. Domingues; Maria R. M. Domingues; Maria G. P. M. S. Neves; José A. S. Cavaleiro; Rosa Fernandes; João P. C. Tomé

doi:10.1039/C4CC02226B

Amphiphilic phthalocyanine–cyclodextrin conjugates for cancer photodynamic therapy†

Leandro M. O. Lourenço,^ab Patrícia M. R. Pereira,^abc Elisabete Maciel,^ab Mónica Válega,^ab Fernando M. J. Domingues,^a Maria R. M. Domingues,^ab Maria G. P. M. S. Neves,^ab José A. S. Cavaleiro,^ab Rosa Fernandes^cd and João P. C. Tomé*^abe

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* Corresponding authors

^a Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal
E-mail: jtome@ua.pt

^b QOPNA, University of Aveiro, 3810-193 Aveiro, Portugal

^c IBILI, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal

^d Center of Investigation in Environment, Genetics and Oncobiology, 3001-301 Coimbra, Portugal

^e Department of Organic Chemistry, Ghent University, B-9000 Gent, Belgium

Abstract

Three phthalocyanines (Pcs) conjugated with α-, β- and γ-cyclodextrins (CDs) were prepared and their application as photosensitizer (PS) agents was assessed by photophysical, photochemical and in vitro photobiological studies. The photoactivity of Pc-α-CD and Pc-γ-CD ensures their potential as PDT drugs against UM-UC-3 human bladder cancer cells.

Chemical Communications

Amphiphilic phthalocyanine–cyclodextrin conjugates for cancer photodynamic therapy†

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