Issue 55, 2014
From the journal:

Chemical Communications

Intracellular gold nanoparticle aggregation and their potential applications in photodynamic therapy†

Yamin Yang,a   Yue Hu,b   Henry Dub  and  Hongjun Wang*a  

* Corresponding authors

a Department of Chemistry, Chemical Biology and Biomedical Engineering, Stevens Institute of Technology, Castle Point on Hudson, Hoboken, NJ 07030, USA
E-mail: Hongjun.Wang@stevens.edu
Fax: +1 201 216 8240
Tel: +1 201 216 5556

b Department of Chemical Engineering and Materials Science, Stevens Institute of Technology, Castle Point on Hudson, Hoboken, NJ 07030, USA

Abstract

Gold nanoparticles (Au NPs) with opposite surface charge can form aggregates through electrostatic interaction and exhibit surface plasmon resonance (SPR) induced-localized electromagnetic (EM) field enhancement under light irradiation. Intracellular aggregation of Au NPs can further improve the therapeutic efficiency of Au NP-enhanced photodynamic therapy of cancer by promoting singlet oxygen generation.

Graphical abstract: Intracellular gold nanoparticle aggregation and their potential applications in photodynamic therapy

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Article information

DOI
https://doi.org/10.1039/C4CC02376E
Article type
Communication
Submitted
31 Mar 2014
Accepted
18 May 2014
First published
20 May 2014

Chem. Commun., 2014,50, 7287-7290

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Intracellular gold nanoparticle aggregation and their potential applications in photodynamic therapy

Y. Yang, Y. Hu, H. Du and H. Wang, Chem. Commun., 2014, 50, 7287 DOI: 10.1039/C4CC02376E

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