Issue 62, 2014
From the journal:

Chemical Communications

An expedient approach to pyrrolo[3,2-c]quinolines via regioselective formation of the pyrrole nucleus over indoles†

Manjusha V. Karkhelikar,a   Rajeev R. Jha,b   B. Sridhar,c   Pravin R. Likhar*a  and  Akhilesh K. Verma*b  

* Corresponding authors

a Organometallic Group, Inorganic and Physical Chemistry Division, Indian Institute of Chemical Technology, Hyderabad-500007, India
E-mail: plikhar@iict.res.in

b Department of Chemistry, University of Delhi, Delhi-110007, India
E-mail: averma@acbr.du.ac.in

c X-Ray Crystallography Center, Indian Institute of Chemical Technology, Hyderabad-500007, India

Abstract

An efficient approach for the synthesis of pyrrolo[3,2-c]quinolines (the core nucleus of the natural product martinellic acid) from protected 2-alkynylanilines via the regioselective formation of pyrroles followed by Heck and intramolecular Michael addition has been described.

Graphical abstract: An expedient approach to pyrrolo[3,2-c]quinolines via regioselective formation of the pyrrole nucleus over indoles

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Article information

DOI
https://doi.org/10.1039/C4CC02466D
Article type
Communication
Submitted
03 Apr 2014
Accepted
07 May 2014
First published
20 Jun 2014

Chem. Commun., 2014,50, 8526-8528

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An expedient approach to pyrrolo[3,2-c]quinolines via regioselective formation of the pyrrole nucleus over indoles

M. V. Karkhelikar, R. R. Jha, B. Sridhar, P. R. Likhar and A. K. Verma, Chem. Commun., 2014, 50, 8526 DOI: 10.1039/C4CC02466D

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