2-Aroylindoles from o-bromochalcones via Cu(i)-catalyzed SNAr with an azide and intramolecular nitrene C–H insertion†
Abstract
A simple procedure for the synthesis of 2-aroylindole derivatives comprising a one-pot CuI-catalyzed SNAr reaction of o-bromochalcones with sodium azide and subsequent intramolecular cyclization through nitrene C–H insertion has been developed. This protocol is also applicable with the 2′-bromocinnamates giving the indole-2-carboxylates.