Issue 63, 2014
From the journal:

Chemical Communications

Inherent anchorages in UiO-66 nanoparticles for efficient capture of alendronate and its mediated release†

Xiangyang Zhu,a   Jinlou Gu,*a   Yao Wang,a   Bing Li,a   Yongsheng Li,a   Wenru Zhaoa  and  Jianlin Shi*a  

* Corresponding authors

a Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China
E-mail: jinlougu@ecust.edu.cn
Fax: +86-21-64250740
Tel: +86-21-64252599

Abstract

Zr-based MOF nanoparticles were applied as efficient carriers for alendronate delivery, and an unprecedented drug loading capacity was achieved thanks to the inherent drug anchorages of Zr–O clusters therein. The encapsulated drug featured with a pH-dependent release profile, and inhibited the growth of cancer cells more efficiently than the free drug.

Graphical abstract: Inherent anchorages in UiO-66 nanoparticles for efficient capture of alendronate and its mediated release

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Article information

DOI
https://doi.org/10.1039/C4CC02570A
Article type
Communication
Submitted
08 Apr 2014
Accepted
12 Jun 2014
First published
12 Jun 2014

Chem. Commun., 2014,50, 8779-8782

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Inherent anchorages in UiO-66 nanoparticles for efficient capture of alendronate and its mediated release

X. Zhu, J. Gu, Y. Wang, B. Li, Y. Li, W. Zhao and J. Shi, Chem. Commun., 2014, 50, 8779 DOI: 10.1039/C4CC02570A

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