Issue 61, 2014
From the journal:

Chemical Communications

The direct synthesis of N-alkylated amides via a tandem hydration/N-alkylation reaction from nitriles, aldoximes and alcohols†

Nana Wang,a   Xiaoyuan Zou,a   Juan Maa  and  Feng Li*a  

* Corresponding authors

a Key Laboratory for Soft Chemistry and Functional Materials, Ministry of Education, Nanjing University of Science and Technology, Nanjing 210094, P. R. China
E-mail: fengli@njust.edu.cn
Fax: +86-25-84431939
Tel: +86-25-84317316

Abstract

A novel strategy for the direct synthesis of N-alkylated amides from nitriles, aldoximes and alcohols was proposed and accomplished in the presence of a Cp*Ir complex.

Graphical abstract: The direct synthesis of N-alkylated amides via a tandem hydration/N-alkylation reaction from nitriles, aldoximes and alcohols

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Article information

DOI
https://doi.org/10.1039/C4CC02742F
Article type
Communication
Submitted
14 Apr 2014
Accepted
02 Jun 2014
First published
03 Jun 2014

Chem. Commun., 2014,50, 8303-8305

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The direct synthesis of N-alkylated amides via a tandem hydration/N-alkylation reaction from nitriles, aldoximes and alcohols

N. Wang, X. Zou, J. Ma and F. Li, Chem. Commun., 2014, 50, 8303 DOI: 10.1039/C4CC02742F

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