Issue 60, 2014

Rhodium-catalyzed direct coupling of biaryl pyridine derivatives with internal alkynes

Abstract

Axially chiral biaryls were synthesized by an isoquinoline or 2-pyridine-directed Rh(III)-catalyzed dual C–H cleavage and coupling with internal alkynes in good to excellent yields. Oxidation of isoquinoline derivatives with m-CPBA furnished their corresponding N-oxides, which could be utilized as Lewis base catalysts in asymmetric reactions.

Graphical abstract: Rhodium-catalyzed direct coupling of biaryl pyridine derivatives with internal alkynes

Supplementary files

Article information

Article type
Communication
Submitted
16 Apr 2014
Accepted
01 Jun 2014
First published
02 Jun 2014

Chem. Commun., 2014,50, 8204-8207

Author version available

Rhodium-catalyzed direct coupling of biaryl pyridine derivatives with internal alkynes

J. Zheng and S. You, Chem. Commun., 2014, 50, 8204 DOI: 10.1039/C4CC02822H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements