Issue 64, 2014
From the journal:

Chemical Communications

Design, synthesis and biological evaluation of mitochondria targeting theranostic agents†

Song Wu,ab   Qizhen Cao,a   Xiaolin Wang,ac   Kai Chenga  and  Zhen Cheng*a  

* Corresponding authors

a Molecular Imaging Program at Stanford (MIPS), Bio-X Program, Department of Radiology, Stanford University, California, USA
E-mail: zcheng@stanford.edu
Fax: +1-650-736-7925
Tel: +1-650-723-7866

b School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, PR China

c Faculty of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, PR China

Abstract

Dual mitochondria targeting fluorescent F16–TPP analogues were designed and synthesized. Uptake and cytotoxicity studies indicate that FF16 and FF16–TPP, two compounds discovered in this study, are promising mitochondria targeting theranostic agents.

Graphical abstract: Design, synthesis and biological evaluation of mitochondria targeting theranostic agents

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Article information

DOI
https://doi.org/10.1039/C4CC03296A
Article type
Communication
Submitted
03 May 2014
Accepted
22 May 2014
First published
22 May 2014

Chem. Commun., 2014,50, 8919-8922

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Design, synthesis and biological evaluation of mitochondria targeting theranostic agents

S. Wu, Q. Cao, X. Wang, K. Cheng and Z. Cheng, Chem. Commun., 2014, 50, 8919 DOI: 10.1039/C4CC03296A

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