Issue 62, 2014
From the journal:

Chemical Communications

Chiral phosphoramide-catalyzed enantioselective synthesis of 2,3′-diindolylarylmethanes from indol-2-yl carbinols and indoles†

Shuai Qi,ab   Chao-You Liu,ab   Jin-Ying Dinga  and  Fu-She Han*ac  

* Corresponding authors

a Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, Jilin 130022, China
E-mail: fshan@ciac.ac.cn

b The University of Chinese Academy of Sciences, Beijing 100864, China

c Key Lab of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, CAS, China

Abstract

We present the first asymmetric reaction of indol-2-yl carbinols with indole derivatives catalyzed by chiral phosphoramides for the enantioselective synthesis of 2,3′-diindolylarylmethanes in excellent yields of over 90% as well as high enantioselectivity of up to 96% ee.

Graphical abstract: Chiral phosphoramide-catalyzed enantioselective synthesis of 2,3′-diindolylarylmethanes from indol-2-yl carbinols and indoles

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Article information

DOI
https://doi.org/10.1039/C4CC03605K
Article type
Communication
Submitted
13 May 2014
Accepted
09 Jun 2014
First published
11 Jun 2014

Chem. Commun., 2014,50, 8605-8608

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Chiral phosphoramide-catalyzed enantioselective synthesis of 2,3′-diindolylarylmethanes from indol-2-yl carbinols and indoles

S. Qi, C. Liu, J. Ding and F. Han, Chem. Commun., 2014, 50, 8605 DOI: 10.1039/C4CC03605K

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