Issue 78, 2014
From the journal:

Chemical Communications

A bifunctional curcumin analogue for two-photon imaging and inhibiting crosslinking of amyloid beta in Alzheimer's disease†

Xueli Zhang,‡ab   Yanli Tian,‡ac   Peng Yuan,d   Yuyan Li,ab   Mohammad A. Yaseen,a   Jaime Grutzendler,d   Anna Moore*a  and  Chongzhao Ran*a  

* Corresponding authors

a Molecular Imaging Laboratory, A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School, Building 75, Charlestown, Massachusetts 02129, USA
E-mail: cran@nmr.mgh.harvard.edu, amoore@helix.mgh.harvard.edu

b School of Pharmacy, China Pharmaceutical University, Nanjing, China

c Department of Parasitology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China

d Department of Neurology, Yale University, New Haven, CT, USA

Abstract

In this report, we designed a highly bright bifunctional curcumin analogue CRANAD-28. In vivo two-photon imaging suggested that CRANAD-28 could penetrate the blood brain barrier (BBB) and label plaques and cerebral amyloid angiopathies (CAAs). We also demonstrated that this imaging probe could inhibit the crosslinking of amyloid beta induced either by copper or by natural conditions.

Graphical abstract: A bifunctional curcumin analogue for two-photon imaging and inhibiting crosslinking of amyloid beta in Alzheimer's disease

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Article information

DOI
https://doi.org/10.1039/C4CC03731F
Article type
Communication
Submitted
16 May 2014
Accepted
22 Jul 2014
First published
06 Aug 2014

Chem. Commun., 2014,50, 11550-11553

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A bifunctional curcumin analogue for two-photon imaging and inhibiting crosslinking of amyloid beta in Alzheimer's disease

X. Zhang, Y. Tian, P. Yuan, Y. Li, M. A. Yaseen, J. Grutzendler, A. Moore and C. Ran, Chem. Commun., 2014, 50, 11550 DOI: 10.1039/C4CC03731F

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