Issue 66, 2014
From the journal:

Chemical Communications

Accumulation of supramolecular nanoparticles self-assembled from a bola-shaped cytidylic acid-appended fluorescein dye in cell nuclei†

Rika Iwaura,*a   Mutsumi Shirai,a   Kaname Yoshidab  and  Mayumi Ohnishi-Kameyamaa  

* Corresponding authors

a National Food Research Institute, National Agriculture and Food Research Organization, 2-1-12 Kannondai, Tsukuba, Ibaraki 305-8642, Japan
E-mail: riwaura@affrc.go.jp

b Japan Fine Ceramics Center, 2-4-1 Mutsuno, Atsuta, Nagoya, Japan

Abstract

We examined the cellular uptake of the nanoparticles self-assembled from a bola-shaped cytidylic acid-appended fluorescein derivative (C-FLU-C). The accumulation of fluorescence in the Caco-2 cell nucleus was observed mainly after the plateau phase of cell growth, indicating that C-FLU-C permeated the nuclear envelope without nuclear-localizing tags.

Graphical abstract: Accumulation of supramolecular nanoparticles self-assembled from a bola-shaped cytidylic acid-appended fluorescein dye in cell nuclei

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Article information

DOI
https://doi.org/10.1039/C4CC03733B
Article type
Communication
Submitted
16 May 2014
Accepted
24 Jun 2014
First published
24 Jun 2014

Chem. Commun., 2014,50, 9295-9297

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Accumulation of supramolecular nanoparticles self-assembled from a bola-shaped cytidylic acid-appended fluorescein dye in cell nuclei

R. Iwaura, M. Shirai, K. Yoshida and M. Ohnishi-Kameyama, Chem. Commun., 2014, 50, 9295 DOI: 10.1039/C4CC03733B

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