Issue 63, 2014
From the journal:

Chemical Communications

Identification of novel inhibitors that disrupt STAT3–DNA interaction from a γ-AApeptide OBOC combinatorial library†

Peng Teng,‡a   Xiaolei Zhang,‡bc   Haifan Wu,a   Qiao Qiao,a   Said M. Sebti*bc  and  Jianfeng Cai*a  

* Corresponding authors

a Department of Chemistry, University of South Florida, 4202 E. Fowler Ave, Tampa, FL 33620, USA
E-mail: jianfengcai@usf.edu
Fax: +1 831-874-3203
Tel: +1 813-974-9506

b Department of Drug Discovery, Chemical Biology and Molecular Medicine Program, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA
E-mail: said.sebti@moffitt.org

c Department of Molecular Medicine, University of South Florida, Tampa, FL 33612, USA

Abstract

From a γ-AApeptide-based one-bead-one-compound (OBOC) combinatorial library, we identified γ-AApeptides that can selectively inhibit STAT3–DNA interaction and suppress the expression levels of STAT3 target genes in intact cells. Our results demonstrate that in addition to the SH2 domain, the DNA binding domain of STAT3 is targetable for the development of a new generation of anti-cancer therapeutics.

Graphical abstract: Identification of novel inhibitors that disrupt STAT3–DNA interaction from a γ-AApeptide OBOC combinatorial library

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C4CC03909B
Article type
Communication
Submitted
22 May 2014
Accepted
09 Jun 2014
First published
09 Jun 2014

Chem. Commun., 2014,50, 8739-8742

Author version available

Download author version (PDF)

Permissions

Request permissions

Identification of novel inhibitors that disrupt STAT3–DNA interaction from a γ-AApeptide OBOC combinatorial library

P. Teng, X. Zhang, H. Wu, Q. Qiao, S. M. Sebti and J. Cai, Chem. Commun., 2014, 50, 8739 DOI: 10.1039/C4CC03909B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements