A highly enantioselective aza-Henry reaction with isatin N-Boc ketimines using a Cu(II)–BOX complex as a catalyst is described. The reaction, which does not require protection of the N1 atom, provides the corresponding nitroamines bearing a quaternary stereocentre with high yields and enantiomeric excesses (up to 99.9%).
M. Holmquist, G. Blay and J. R. Pedro, Chem. Commun., 2014, 50, 9309 DOI: 10.1039/C4CC04051A
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