Issue 64, 2014

Synthesis of N-aryl substituted, five- and six-membered azacycles using aluminum-amide complexes

Abstract

Synthesis of N-aryl substituted, five- and six-membered azacycloalkanes, isoindolines and tetrahydroisoquinolines, has been described. In this synthesis, cyclic ethers (n = 1, 2) were treated with dimethylaluminum-amide reagents, derived from a range of aryl amines and trimethylaluminum, to afford the corresponding azacycles in good yields.

Graphical abstract: Synthesis of N-aryl substituted, five- and six-membered azacycles using aluminum-amide complexes

Supplementary files

Article information

Article type
Communication
Submitted
29 May 2014
Accepted
17 Jun 2014
First published
19 Jun 2014

Chem. Commun., 2014,50, 8985-8988

Author version available

Synthesis of N-aryl substituted, five- and six-membered azacycles using aluminum-amide complexes

B. L. Korbad and S. Lee, Chem. Commun., 2014, 50, 8985 DOI: 10.1039/C4CC04111A

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