Issue 83, 2014
From the journal:

Chemical Communications

Sulfonyl azide-mediated norbornene aziridination for orthogonal peptide and protein labeling†

Michael J. Gattner,a   Michael Ehrlicha  and  Milan Vrabel‡*a  

* Corresponding authors

a Department of Chemistry, Ludwig-Maximilians-University, Butenandtstrasse 5-13, 81377 Munich, Germany

Abstract

We describe a new bioconjugation reaction based on the aziridination of norbornenes using electron-deficient sulfonyl azides. The reaction enables to attach various useful tags to peptides and proteins under mild conditions.

Graphical abstract: Sulfonyl azide-mediated norbornene aziridination for orthogonal peptide and protein labeling

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Article information

DOI
https://doi.org/10.1039/C4CC04117H
Article type
Communication
Submitted
29 May 2014
Accepted
27 Aug 2014
First published
29 Aug 2014

Chem. Commun., 2014,50, 12568-12571

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Sulfonyl azide-mediated norbornene aziridination for orthogonal peptide and protein labeling

M. J. Gattner, M. Ehrlich and M. Vrabel, Chem. Commun., 2014, 50, 12568 DOI: 10.1039/C4CC04117H

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