Issue 73, 2014
From the journal:

Chemical Communications

Smart dual-functional warhead for folate receptor-specific activatable imaging and photodynamic therapy†

Jisu Kim,a   Ching-Hsuan Tungb  and  Yongdoo Choi*a  

* Corresponding authors

a Molecular Imaging & Therapy Branch, National Cancer Center, 323 Ilsan-ro, Goyang-si, Gyeonggi-do 410-769, Korea
E-mail: ydchoi@ncc.re.kr
Fax: +82-31-920-2529
Tel: +82-31-920-2512

b Molecular Imaging Innovations Institute, Department of Radiology, Weil Cornell Medical College, New York, NY 10065, USA

Abstract

A smart dual-targeted theranostic agent becomes highly fluorescent and phototoxic only when its linker is cleaved by tumor-associated lysosomal enzyme cathepsin B after internalization into folate receptor-positive cancer cells.

Graphical abstract: Smart dual-functional warhead for folate receptor-specific activatable imaging and photodynamic therapy

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Article information

DOI
https://doi.org/10.1039/C4CC04166F
Article type
Communication
Submitted
30 May 2014
Accepted
28 Jul 2014
First published
28 Jul 2014

Chem. Commun., 2014,50, 10600-10603

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Smart dual-functional warhead for folate receptor-specific activatable imaging and photodynamic therapy

J. Kim, C. Tung and Y. Choi, Chem. Commun., 2014, 50, 10600 DOI: 10.1039/C4CC04166F

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