The meta-iodo derivative, fixed in the cone conformation, enables the gram-scale preparation of a meta-bridged calix[4]arene. This intermediate, possessing a fluorene moiety within the macrocyclic skeleton, can be regioselectively alkylated on the corresponding methylene bridge to form a unique substitution pattern in classical calixarene chemistry.
![Graphical abstract: Regioselective alkylation of a methylene group via meta-bridging of calix[4]arenes](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C4CC04356A&imageInfo.ImageIdentifier.Year=2014)
P. Slavík, H. Dvořáková, V. Eigner and P. Lhoták, Chem. Commun., 2014, 50, 10112 DOI: 10.1039/C4CC04356A
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