A crystal structure of lysozyme in complex with p-sulfonato-calix[4]arene (sclx4) reveals a linear assembly of protein tetramers glued together by protein–calixarene interactions. One interaction involves encapsulation of the highly exposed C-terminal Arg128. The other involves an intricate protein-bound complex of sclx4, Mg2+ and a fragment of polyethylene glycol.
![Graphical abstract: Protein assembly mediated by sulfonatocalix[4]arene](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C4CC04897K&imageInfo.ImageIdentifier.Year=2014)
R. E. McGovern, A. A. McCarthy and P. B. Crowley, Chem. Commun., 2014, 50, 10412 DOI: 10.1039/C4CC04897K
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